What do you think brought about the downfall of Lady Macbeth? There were several aspects of Shakespeare’s novel ‘Macbeth’ that led to the downfall of Lady Macbeth. The mentality of Lady Macbeth in the play changes dramatically from the wife a Noble General, to an evil aggressive murderer (brought upon by the witches predictions), and finally a woman who had de-graded to such an extent that she took her own life. We are not told an awful amount about Lady Macbeth at the start of the play [prior to her letter from Macbeth about the witche ....