Loneliness is the central theme in the novel Of Mice and Men. Many of the characters show signs of being lonely, some more than others. Loneliness haunts Crooks deep inside. Crooks accepts things the way they are though. Crooks does not talk to the other men and they do not talk to him. This causes the greatest amount of loneliness in Crooks out of all the characters. Rejection can cause most people to become crazy, as it did to Crooks. Other characters on the ranch show signs of loneliness also. But what makes the others different is ....