Hundreds of years ago, humans were plagued with "crazy fear". Then the Greeks blamed an imbalance of black bile for the melancholia suffered by so many people. Centuries later, in a country where Prozac and PMS jokes are part of the cultural landscape, we have a new term for our "craziness", our melancholy-, or major depressive disorder. And along with our relatively newfound label, the heightened interest in has opened up a host of theories, myths, and treatments that seek to explain the oldest mental illness in written history. Affecting o ....