All the research and studies combined found that Tamoxifen is a safe and effective treatment for breast cancer. In a case of long-term treatment, possible side effects have to be monitored and the most serious side effects involve the genital tract. the gynecologist has an important role to play. They should be aware of urine and ovarian pathological conditions. They should also consider the impact of hormonal treatment on other systems and functions. I think that there is a lot more research to be done. Women unsure of continuing on ....